Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas

• DOI: 10.3389/fcell.2021.667796
• Publication Date: 2021-09-20T05:02:21Z
• Authors: Raquel Lourenço; Ana S. Brandão; Jorge Borbinha; Rita Gorgulho; António Jacinto
• Keywords: Muller glia; Reprogramming; Retinal regeneration

Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, light-induced photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise a self-renewing population progenitors that migrate lesion site differentiate into new photoreceptors. The Hippo pathway effector YAP was recently implicated in response damage retina, but how this transcription coactivator integrated signaling network regulating has not yet been explored. Here, we show Yap required engage by cell cycle reentry progenitor formation, contributing differentiation We propose regulation accomplished lin28a – ascl1a -dependent mechanism, bona fide glia-reprogramming factors. Overall, study presents key regulator consequently injury.