Circulating Exosomal MiR-107 Restrains Tumorigenesis in Diffuse Large B-Cell Lymphoma by Targeting 14-3-3η

• DOI: 10.3389/fcell.2021.667800
• Publication Date: 2021-04-27T08:58:42Z
• Authors: Jiarui Liu; Yang Han; Shunfeng Hu; Yiqing Cai; Juan Yang; Shuai Ren; Yi Zhao; Tiange Lu; Xiangxiang Zhou; Xin Wang
• Keywords: Exosome

Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate role exosomal miR-107 lymphomagenesis and explore its clinical significance. In this study, decreased miR-107, miR-375-3p, upregulated miR-485-3p were detected plasma DLBCL patients showed potential diagnostic value. Downregulated expression was associated with advanced Ann Arbor stage, high IPI score, LDH, β 2 -MG level patients. Overexpression by Agomir significantly abrogated cell proliferation, induced apoptosis, inhibited invasion vitro , repressed tumor growth vivo . Moreover, downregulation went opposite direction. The target genes mainly enriched PI3K-Akt, Hippo, AMPK signaling pathways. Notably, 14-3-3η (YWHAH) suppressed DLBCL, suggesting that may restrain tumorigenesis targeting 14-3-3η. summary, unveils lymphomagenesis, highlighting a prognostic indicator new therapeutic management DLBCL.