Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity

• DOI: 10.3389/fcell.2021.689028
• Publication Date: 2021-07-01T13:42:21Z
• Authors: Xinhui Li; Jian Zhou; Mingming Xiao; Lingyu Zhao; Yan Zhao; Shuoshuo Wang; Shuangshu Gao; Yuan Zhuang; Yi Niu; Shijun Li; Xiaobo Li; Yuanyuan Zhu; Minghui Zhang; Jing Tang
• Keywords: molecular subtypes; 0303 health sciences; immune infiltration; QH301-705.5; driver gene; Cell Biology; 3. Good health; Cell and Developmental Biology; 03 medical and health sciences; breast cancer; prognosis; Biology (General); Developmental Biology

Breast cancer is a heterogeneous malignant disease with different prognoses and has been divided into four molecular subtypes. It believed that events occurring in breast stem/progenitor cells contribute to the carcinogenesis development of However, these subtype-specific characteristics are largely unknown. In this study, we employed 1217 samples from The Cancer Genome Atlas (TCGA) database for multiomics analysis subtypes based on PAM50 algorithms. We detected expression changes genes revealed particular significantly affected prognosis. also investigated mutations copy number variations (CNVs) driver representative ten signaling pathways several subtype-specifically altered genes. Moreover, infiltration various immune showed levels major cell types among Additionally, factors affecting level cytolytic activity subtypes, namely, mutation burden, genome instability cancer-associated fibroblast (CAF) infiltration. This study may shed light contributing provide potential markers targets clinical diagnosis treatment