Pan-Cancer Analysis Reveals That E1A Binding Protein p300 Mutations Increase Genome Instability and Antitumor Immunity

• DOI: 10.3389/fcell.2021.729927
• Publication Date: 2021-09-20T05:29:57Z
• Authors: Zuobing Chen; Canping Chen; Lin Li; Tianfang Zhang; Xiaosheng Wang
• Keywords: Microsatellite Instability

E1A binding protein p300 ( EP300 ) is mutated in diverse cancers. Nevertheless, a systematic investigation into the associations of mutations with genome instability and antitumor immunity pan-cancer remains lacking. Using datasets from The Cancer Genome Atlas, we analyzed correlations between immune response 11 cancer types. Compared to -wild-type cancers, -mutated cancers had significantly higher tumor mutation burden (TMB) 10 harbored much fraction microsatellite instable colon gastric was co-mutated genes involved DNA damage repair pathways multiple Furthermore, compared cytolytic activity scores ratios immune-stimulatory over immune-inhibitory signatures Also, showed programmed death-ligand 1 PD-L1 expression levels than increased TMB, activity, indicated favorable checkpoint inhibitors (ICIs) as evident three cohorts treated ICIs. Thus, could be predictive biomarker for immunotherapy.