Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value

• DOI: 10.3389/fcell.2021.760618
• Publication Date: 2022-07-04T05:41:26Z
• Authors: Xuanwen Bao; Kun Wang; Ming Liu; Bin Li; Hongwei Wang; Kemin Jin; Xiaoluan Yan; Hangyu Zhang; Quan Bao; Da Xu; Lijun Wang; Wei Liu; Yanyan Wang; Juan Li; Lijuan Liu; Weijia Fang; Baocai Xing
• Keywords: mutation signature; 0301 basic medicine; Cell and Developmental Biology; 03 medical and health sciences; colorectal liver metastases; prognostics; QH301-705.5; overall survival; genomic landscape; Biology (General)

Colorectal liver metastases (CRLMs) are clinically heterogeneous lesions with poor prognosis. Genetic alterations play a crucial role in their progression. The traditional Fong clinical risk score (Fong-CRS) is commonly used for risk stratification and prognosis prediction. By identifying the genomic alterations of CRLMs, we aimed to develop a mutation-based gene-signature-based clinical score (mut-CS) system to improve clinical prognostication. Tumour tissues from 144 patients with CRLMs were analysed with next-generation sequencing (NGS). A mut-CS scoring system considering the unique mutation-based gene signature, primary site, and Fong-CRS was developed and could identify CRLM patients with poor prognosis. The mean time-dependent receiver operating characteristic curve AUC value of the mut-CS system was greater than that of previously established scoring measures (the Fong-CRS, the e-clinical score, the presence of concomitant RAS and TP53 mutations, and other clinical traits). Taking together, we identified a mutant signature that exhibits a strong prognostic effect for CRLMs. Traditional clinical scoring system characteristics were incorporated into the new mut-CS scoring system to help determine the appropriate treatment for CRLMs.