Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway

• DOI: 10.3389/fcell.2021.766512
• Publication Date: 2021-11-18T09:51:40Z
• Authors: Wenqi Liang; Chunli Zhao; Zhongrui Chen; Zijing Yang; Ke Liu; Shusheng Gong
• Keywords: SOD2; SIRT3; Noise-induced hearing loss

Mitochondrial oxidative stress is involved in hair cell damage caused by noise-induced hearing loss (NIHL). Sirtuin-3 (SIRT3) plays an important role survival regulating mitochondrial function; however, the of SIRT3 NIHL unknown. In this study, we used 3-TYP to inhibit and found that inhibition aggravated cells mice with NIHL. Moreover, reduced enzymatic activity deacetylation levels superoxide dismutase 2 (SOD2). Subsequently, administered adeno-associated virus-SIRT3 posterior semicircular canals overexpression significantly attenuated injury protective effect could be blocked 2-methoxyestradiol, a SOD2 inhibitor. These findings suggest insufficient SIRT3/SOD2 signaling leads resulting Thus, ameliorating redox imbalance intervening pathway may new therapeutic target for injury.