Mitophagy-Related Gene Signature for Prediction Prognosis, Immune Scenery, Mutation, and Chemotherapy Response in Pancreatic Cancer

• DOI: 10.3389/fcell.2021.802528
• Publication Date: 2022-02-07T16:23:54Z
• Authors: Zewei Zhuo; Hanying Lin; Jun Liang; Pengyue Ma; Jingwei Li; Lin Huang; Lishan Chen; Hongwei Yang; Yang Bai; Weihong Sha
• Keywords: Gene signature

Mitophagy is a conserved cellular process that plays vital role in maintaining homeostasis by selectively removing dysfunctional mitochondria. Notwithstanding growing evidence suggests mitophagy implicated pancreatic tumorigenesis, the effect of mitophagy-related genes on cancer (PC) prognosis and therapeutic response remains largely unknown. In this study, we sought to construct gene signature assessed its ability predict survival, immune activity, mutation status, chemotherapy PC patients. During screening process, identified three (PRKN, SRC, VDAC1) from The Cancer Genome Atlas (TCGA) cohort 3-gene was established. prognostic model validated using an International Consortium (ICGC) two Gene Expression Omnibus (GEO) cohorts. According median risk score, patients were divided into high low-risk groups, high-risk group correlated with worse survival four score then as independent predictor, predictive nomogram constructed guide clinical decision-making. Remarkably, enhanced immunosuppressive levels higher rates observed group, which may account for their poor survival. Furthermore, found more sensitive paclitaxel erlotinib. conclusion, novel can be used indicator allows stratification