Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

• DOI: 10.3389/fcell.2022.815205
• Publication Date: 2022-03-10T11:56:12Z
• Authors: Hyosuk Kim; Yeongji Jang; Eun Hye Kim; Hochung Jang; Haeun Cho; Geonhee Han; Hyun Kyu Song; Sun Hwa Kim; Yoosoo Yang
• Keywords: Hair cycle; Dermal papillae; Exosome; Minoxidil

Human hair dermal papillary (DP) cells comprising mesenchymal stem in follicles contribute critically to growth and cycle regulation. The transition of from telogen anagen phase is the key regulating growth, which relies heavily on activation DP cells. In this paper, we suggested exosomes derived bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for loss. Results showed that Milk-exo promoted proliferation rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest follicle development. also induced dorsal re-growth mice at level comparable minoxidil treatment, without associated adverse effects such skin rashes. Our data demonstrated accelerated by activating Wnt/β-catenin pathway. Interestingly, has been found stably retain its original properties efficacy regeneration after freeze-drying resuspension, considered critical use it raw material applied different types alopecia medicines treatments. Overall, study highlights great potential an exosome therapeutic modality