Autocrine/Paracrine Slit–Robo Signaling Controls Optic Lobe Development in Drosophila melanogaster

• DOI: 10.3389/fcell.2022.874362
• Publication Date: 2022-07-25T06:36:10Z
• Authors: M. Constanza Gonz...; Francisca Rojo-Co...; Noemí Candia; Jorge Garay-Monte...; Pablo Guzmán-Palma; Jorge M. Campusano; Carlos Oliva
• Keywords: Slit

Cell segregation mechanisms play essential roles during the development of central nervous system (CNS) to support its organization into distinct compartments. The Slit protein is a secreted signal, classically considered paracrine repellent for axonal growth through Robo receptors. However, function in compartmentalization CNS less explored. In this work, we show that and Robo3 are expressed same neuronal population Drosophila optic lobe, where they required correct lobe neuropils by action an autocrine/paracrine mechanism. We characterize endocytic route followed Slit/Robo3 complex detected genetic interactions with genes involved endocytosis actin dynamics. Thus, report Slit-Robo3 pathway regulates morphogenesis atypical mechanism addition role axon guidance, association proteins small GTPases.