Integrated Analysis of Glutathione Metabolic Pathway in Pancreatic Cancer

• DOI: 10.3389/fcell.2022.896136
• Publication Date: 2022-06-03T09:47:31Z
• Authors: Xingui Wu; Ruyuan Yu; Meisongzhu Yang; Yameng Hu; Miaoling Tang; Shuxia Zhang; Ainiwaerjiang Abu...; Xincheng Li; Ziwen Li; Xinyi Liao; Yingru Xu; Man Li; Suwen Chen; Wanying Qian; Rongni Feng; Jun Li; Fenjie Li
• Keywords: Metabolic pathway; Pathway Analysis

Metabolic enzyme-genes (MEs) play critical roles in various types of cancers. However, MEs have not been systematically and thoroughly studied pancreatic cancer (PC). Global analysis PC will help us to understand progressing provide new insights into therapy. In this study, we analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) (n = 180 + 4) GSE15471 36 36) discovered that metabolic pathways are disordered PC. Co-expression network modules were constructed using weighted gene co-expression (WGCNA), which identified two key modules. Both revealed the glutathione signaling pathway is correlated with stages. Notably, peroxidase 2 ( GPX2 ), an important involved pathway, a hub Analysis immune microenvironment components reveals stage associated M2 macrophages, marker significantly . results indicated progression, providing for future targeted