Gut Microbiota Signatures in Tumor, Para-Cancerous, Normal Mucosa, and Feces in Colorectal Cancer Patients

• DOI: 10.3389/fcell.2022.916961
• Publication Date: 2022-06-02T10:30:03Z
• Authors: Yanmin Li; Hong Cao; Bojian Fei; Qizhong Gao; Wanya Yi; Weifeng Han; Chuanqing Bao; Jianmin Xu; Wei Zhao; Feng Zhang
• Keywords: Intestinal mucosa

Background: Association studies have linked microbiome alterations with colorectal cancer (CRC). However, differences in tumor, para-cancerous, normal mucosal, and fecal microbiota remain to be strengthened. Methods: We performed a study on the ecologically rich taxonomically diverse of gut using three types mucosa (tumor mucosa, para-cancerous mucosa) feces from 98 CRC patients. Additionally, we profiled occult blood test (FOBT) positive negative groups at different sampling sites. Results: found striking variations between tumor mucosal microbiota. there was no significant difference microbiota, as well revealing that transitional state And substantial shifts compared indicated risk define A strong correlation FOBT Fusobacterium discovered, indicating this adherent-invasive genus closely related intestinal bleeding. Furthermore, identified six key genera, including Fusobacterium, Gemella, Campylobacter, Peptostreptococcus, Alloprevotella, Parvimonas, which appear consistently over-represented and/or feces. Conclusion: Compositional existed Six genera may contribute topographic variances tumor-bearing colorectum.