Identification of a prognostic model using cuproptosis-related genes in uveal melanoma

• DOI: 10.3389/fcell.2022.973073
• Publication Date: 2022-08-30T07:08:47Z
• Authors: Yao Chen; Xiaozhen Chen; Xianggui Wang
• Keywords: 0301 basic medicine; Cell and Developmental Biology; 03 medical and health sciences; cuproptosis; QH301-705.5; prognosis; uveal melanoma; bioinfomatics; Biology (General); signature; 3. Good health

The most common intraocular malignancy in adults remains uveal melanoma (UVM), and those with metastatic disease have a poor outlook. Proliferation, angiogenesis, metastasis of tumor cells can be triggered by cuproptosis, affecting the survival cancer patients. Nonetheless, cuproptosis-related genes (CRGs) not been identified UVM. In this study, we analyzed 10 CRGs 80 patients UVM Cancer Genome Atlas (TCGA) database regarding alterations including copy number variation methylation. We further constructed prognostic gene model using these built risk score formula. Univariate multivariate Cox regression was applied to validate as an independent factor. validated 63 samples from GSE22138 cohort, validation data set. Based on scores for TCGA, categorized into high- low-risk groups. Differentially expressed (DEGs) between groups were enriched allograft rejection, hypoxia, glycolysis, TNFα signaling via NF-κB, interferon-γ responses Gene set enrichment analysis (GSEA). CD8 T exhausted notably high-risk group. conclusion, alteration is related UVM, CRG-related may helpful predict prognosis such