The prognostic marker FLVCR2 associated with tumor progression and immune infiltration for acute myeloid leukemia

• DOI: 10.3389/fcell.2022.978786
• Publication Date: 2022-10-12T07:37:41Z
• Authors: Xiuhua Su; Guangxin Ma; Xiaoran Bai; Juan Zhang; Mingying Li; Fan Zhang; Tao Sun; Daoxin Ma; Fei Lu; Chunyan Ji
• Keywords: 0301 basic medicine; Cell and Developmental Biology; 03 medical and health sciences; QH301-705.5; immune cell infiltration; tumor microenvironment; prognosis; acute myeloid leukemia; Biology (General); FLVCR2; 3. Good health

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies in adults. The tumor microenvironment (TME) has a critical effect on AML occurrence, recurrence, and progression. gene feline virus subgroup C cellular receptor family member 2 (FLVCR2) belongs to major facilitator superfamily transporter protein members, which primarily involved transporting small molecules. potential role FLVCR2 TME not been investigated. To clarify expression AML, we analyzed Gene Expression Omnibus Cancer Genome Atlas databases found that mRNA significantly increased among patients with AML. Furthermore, based an analysis Profiling Interactive Analysis database, upregulation predicted dismal overall survival Our validation revealed significant within bone marrow relative healthy controls by western blotting qPCR assays. set enrichment was conducted explore FLVCR2's related mechanism We high infiltration degrees immune cells scores cases, indicating possibly had crucial progression through response. Specifically, negatively activated natural killer cells, memory CD4+ T dendritic CD8+ using CIBERSORT analysis. According vitro research, silencing suppressed cell growth promoted their apoptosis. This study provides insights into immunity, it might serve as independent prognostic biomarker