Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

• DOI: 10.3389/fcell.2024.1252064
• Publication Date: 2024-03-13T04:18:07Z
• Authors: Qianzi Liu; Linxi Lv; Xueding Cai; Jiandong Zhu; Jifa Li; Lehe Yang; Xiaona Xie; Chengguang Zhao; Haiyang Zhao
• Keywords: Demethylase; N6-Methyladenosine; RNA methylation

N 6 -methyladenosine (m A) is the most abundant chemical modification in eukaryotic cells. It a post-transcriptional of mRNA, dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, unique iron-dependent cell death, regulated various metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce inhibit onset through targets mechanisms. They potential clinical value treatment diverse diseases. Until now, it has shown several cancer diseases m A be involved regulation ferroptosis, which impact subsequent treatment. This paper focuses on concept, function, biological role methylation interaction between to provide new therapeutic strategies for treating malignant protecting organism targeting regulate ferroptosis.