Composite nanoparticle-based vesicles achieve enhanced delivery effects of the natural plant extract of the root, stem, and fruit

• DOI: 10.3389/fchem.2025.1552298
• Publication Date: 2025-03-17T07:20:01Z
• Authors: Xiaodong Zhuang; Ting Ma; Risheng Liu; Xingyue Fang; Liangjiu Huang

The extract of medicinal plants is increasingly popular around the whole world due to its attractive therapeutic effects. However, bioavailability bioactive compounds was barely satisfactory easily deactivated and untargeted properties. use nanotechnology develop novel carrier delivery techniques for extracts has been proven have significant potential provides an amazing improvement in effect. Calcium carbonate nanoparticles (CaCO3 NPs), as representative biodegradable materials, are well recognized environmentally responsive vehicles disease treatment. In this study, root ginseng, fruit Alpinia oxyphylla Miq., stem Millettia speciosa Champ. were developed a CaCO3 nanoparticle loading drug. All three composite exhibited spherical shapes with narrow size distribution. Notably, ginseng extract-loaded NPs hold relatively higher entrapment efficiency up 55.2% ± 6.7% excellent release performance under acidic conditions (pH = 5.5). Moreover, intravenous injection resulted significantly enhanced effects treatment glioma. results demonstrate that CaCO3-based ideal plant extracts, systems expected be effective against various types diseases future.