Vitamin D3 Inhibits Helicobacter pylori Infection by Activating the VitD3/VDR-CAMP Pathway in Mice

• DOI: 10.3389/fcimb.2020.566730
• Publication Date: 2020-10-23T13:20:54Z
• Authors: Anni Zhou; Lei Li; Guiping Zhao; Li Min; Si Liu; Shengtao Zhu; Qingdong Guo; Chunjie Liu; Shutian Zhang; Peng Li
• Keywords: Cathelicidin

Helicobacter pylori (H. pylori) infection is closely associated with the occurrence and development of gastric diseases. Therefore, eliminating H. should help to prevent Vitamin D3 (VitD3, 1,25(OH)2D3) was previously observed have anti-H. activity in clinic, but these results were reported heterogeneous vivo studies without elucidation underlying mechanisms. In present study, we established models both wild-type VDR knockdown (VDR-KD) mice, which used demonstrate that VitD3 inhibits by enhancing expression VitD receptor (VDR) cathelicidin antimicrobial peptide (CAMP). Furthermore, VDR-KD mice exhibited lower more susceptible infection. cultured mouse primary epithelial cells, further demonstrated VitD3/VDR complex binds CAMP promoter region increase its expression. These data provide a mechanistic explanation at molecular level suggests new avenue for clinical management eradication therapy.