Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha

• DOI: 10.3389/fcimb.2021.656393
• Publication Date: 2021-07-07T07:51:50Z
• Authors: Andréa Marques Vi...; Lucia Elena Alvar...; Tamiris Azamor; Leonardo Ribeiro ...; Thyago Leal-Calvo; Ohanna Cavalcanti...; Marcelo Ribeiro-A...; Fernanda de Souza...; Patrícia Cristina...; Camilla Bayma; Jane da Silva; Alessandro Fonsec...; Marcelo Muller; Elisabete Ferreir...; Ana Carolina Maga...; Eliane Matos dos ...; Janaína Reis Xavier; Maria De Lourdes ...; Rolando Páez Meir...; Hugo Nodarse Cuni; Guilherme Becker ...; Paulo Dornelles P...; Denise C S Matos; Milton Ozório Moraes
• Keywords: Pegylated interferon

Sustained virologic response (SVR) in chronic hepatitis C (CHC) treatment denotes that the host genetics controls immune and unequivocally contribute to viral clearance or disease severity. In this context, single nucleotide polymorphisms (SNPs) locus of interferon lambda 3 4 genes (