Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

• DOI: 10.3389/fcimb.2021.723856
• Publication Date: 2021-10-14T08:27:23Z
• Authors: Tuo Chen; Rong Wang; Zhenglan Duan; Xiaomin Yuan; Yang Ding; Zeyu Feng; Fan Bu; Li Liu; Qiong Wang; Jinyong Zhou; Lei Zhu; Qing Ni; Guoping Shi; Yugen Chen
• Keywords: Akkermansia muciniphila; Akkermansia; Dysbiosis

Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), composition, mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in disruption mucus, aggravation colitis. In addition, abundance Akkermansia muciniphila was significantly decreased UC patients depression, positively expression MUC2. After antibiotic treatment, recipient colonized showed defects Administration found to restore modify microbiota. confirm CRS-mediated results damage Our suggest A. is expected be a potential probiotic protect treat involved IBD psychological disorders.