WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey

• DOI: 10.3389/fcimb.2021.835946
• Publication Date: 2022-03-11T10:32:39Z
• Authors: Hongwei Zhao; Wenmiao Xu; Lijuan Wang; Yun Zhu; Xiaohui Wang; Yingchao Liu; Junhong Ai; Qianyu Feng; Li Deng; Yun Sun; Changchong Li; Rong Jin; Yunxiao Shang; Hengmiao Gao; Suyun Qian; Lili Xu; Zhengde Xie
• Keywords: Polyomavirus Infections; Rhinovirus; Respiratory tract

WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV real causative agent for diseases. In this study, we described two patients with fatal infection who had their nasopharyngeal swabs. Furthermore, conducted multicentre study six hospitals from different districts China. was by real-time polymerase chain reaction assays, and clinical molecular epidemiological characteristics strains among hospitalized children acute lower infections all around China 2017 to 2019 were analysed. Two complete genome sequences assembled patients’ airway Phylogenetic tree analysis revealed that they most closely related derived Fujian Chongqing, China, 2008 2013, respectively. 2017–2019, total 1,812 samples WUPyV, which 11 (0.6%) positive. Children aged ≤5 more susceptible infection. A 81.8% WUPyV-positive coinfected other viruses, rhinovirus enjoyed highest frequency. The main symptoms infected include fever, coughing sputum expectoration. Most diagnosed pneumonia, followed bronchial surgery. Three manifested severe infection, improved discharged. Our results show persistently circulates Further investigations on role pathogenicity are necessary.