The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis
Oral Microbiome
Prevotella
Prevotella intermedia
DOI:
10.3389/fcimb.2022.1047607
Publication Date:
2022-12-01T19:29:53Z
AUTHORS (13)
ABSTRACT
Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified dominant bacteria and potential pathway in young women with stage-III periodontitis. Samples subgingival plaque were collected from 26 periodontitis (20 stage-I 6 stage-III). Using 16S rRNA-sequencing, we determined variation bacterial communities two groups, each group. used Kyoto Encyclopedia Genes Genomes (KEGG) database evaluate signaling pathways difference composition. The role was investigated vivo vitro using an endoplasmic reticulum stress inhibitor. Young had higher values for Chao1 Index, Observed Species Phylogenetic Diversity Whole Tree Index than those β-diversity analyses revealed that samples could be divided into different groups according stage. most representative biomarkers phylum Bacteroidetes, its order, family genera Bacteroidales, Prevotellaceae Prevotella. KEGG change composition may protein processing pathway. Salubrinal (an regulator) controlled expression Runx2, Col1a1, Ocn mouse bone-marrow mesenchymal cells. administration showed moderate inhibited alveolar bone loss induced by Prevotella intermedia lipopolysaccharide. Differences between stages noted species abundant This phenomenon
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