Nasopharyngeal Bacterial Microbiota Composition and SARS-CoV-2 IgG Antibody Maintenance in Asymptomatic/Paucisymptomatic Subjects

• DOI: 10.3389/fcimb.2022.882302
• Publication Date: 2022-07-07T09:08:35Z
• Authors: Luca Ferrari; Chiara Favero; Giulia Solazzo; Jacopo Mariani; Anna Luganini; Monica Ferraroni; Emanuele Montomoli; Gregorio Paolo Mi...; Valentina Bollati
• Keywords: SARS-CoV-2; Microbiota; immunoglobulins; COVID-19; Antibodies, Viral; UNICORN; Microbiology; QR1-502; Cellular and Infection Microbiology; Immunoglobulin G; Nasopharynx; SARS-CoV-2; UNICORN; asymptomatic carriers; immunoglobulins; nasopharyngeal bacterial microbiota; nasopharyngeal bacterial microbiota; Humans; RNA, Viral; asymptomatic carriers; SARS-CoV-2; UNICORN; asymptomatic carriers; immunoglobulins; nasopharyngeal bacterial microbiota; Antibodies, Viral; Humans; Immunoglobulin G; Nasopharynx; RNA, Viral; SARS-CoV-2; COVID-19; Microbiota

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the disease 2019 (COVID-19), ranging from asymptomatic conditions to severe/fatal lung injury and multi-organ failure. Growing evidence shows that nasopharyngeal microbiota composition may predict severity of infections play a role in protection viral entry regulation immune response infection. In present study, we have characterized bacterial (BNM) performed factor analysis group 54 asymptomatic/paucisymptomatic subjects who tested positive for swab SARS-CoV-2 RNA and/or showed anti-RBD-IgG serology at enrolment. We investigated whether BNM was associated with positivity serum antibody development/maintenance 20–28 weeks after Shannon’s entropy α-diversity index [odds ratio (OR) = 5.75, p 0.0107] Factor1 (OR 2.64, 0.0370) were positively maintenance. results suggest influence immunological memory against infections. To best our knowledge, this is first study investigating link between specific IgG Further studies are needed unveil mechanisms through which influences adaptive