Clinical characteristics and risk factors associated with ICU-acquired infections in sepsis: A retrospective cohort study

• DOI: 10.3389/fcimb.2022.962470
• Publication Date: 2022-07-28T10:13:50Z
• Authors: Yajun He; Jiqian Xu; Xiaopu Shang; Xiangzhi Fang; Chenggang Gao; Deyi Sun; Lu Yao; Ting Zhou; Shangwen Pan; Xiaojing Zou; Huaqing Shu; Xiaobo Yang; You Shang
• Keywords: SAPS II; SOFA score; Central venous catheter; Procalcitonin; Nomogram; Bacteremia

Intensive care unit (ICU)-acquired infection is a common cause of poor prognosis sepsis in the ICU. However, sepsis-associated ICU-acquired infections have not been fully characterized. The study aims to assess risk factors and develop model that predicts patients with sepsis. Methods We retrieved data from Medical Information Mart for Care (MIMIC) IV database. Patients were randomly divided into training validation cohorts at 7:3 ratio. A multivariable logistic regression was used identify independent could predict infection. also assessed its discrimination calibration abilities compared them classical score systems. Results Of 16,808 included septic patients, 2,871 (17.1%) developed These had 17.7% ICU mortality 31.8% in-hospital showed continued rise 28 100 days after admission. Systemic Inflammatory Response Syndrome Score (SIRS), Sequential Organ Failure Assessment (SOFA), Oxford Acute Severity Illness (OASIS), Simplified Physiology II (SAPS II), Logistic Dysfunction (LODS), Charlson Comorbidity Index (CCI), III (APS III) scores associated infection, cerebrovascular insufficiency, Gram-negative bacteria, surgical ICU, tracheostomy, central venous catheter, urinary mechanical ventilation, red blood cell (RBC) transfusion, LODS anticoagulant therapy predictors developing patients. nomogram on basis these good both derivation (AUROC = 0.737; 95% CI, 0.725–0.749) 0.751; 0.734–0.769) populations superior SIRS, SOFA, OASIS, SAPS II, LODS, CCI, APS models. Conclusions increase likelihood mortality. individualized prognostic accurately optimize management or tailored therapy.