Saliva microbiome changes in thyroid cancer and thyroid nodules patients

• DOI: 10.3389/fcimb.2022.989188
• Publication Date: 2022-08-11T10:32:39Z
• Authors: Junjun Jiao; Youli Zheng; Qingyu Zhang; Degeng Xia; Li Zhang; Ning Ma
• Keywords: Thyroid Nodules

Objective Thyroid disease has been reported to associate with gut microbiota, but the effects of thyroid cancer and nodules on oral microbiota are still largely unknown. This study aimed identify variation in salivary their potential association nodules. Methods We used 16S rRNA high-throughput sequencing examine patients (n = 14), 9), healthy controls 15). Results The alpha-diversity indices Chao1 ACE were found be relatively higher compared controls. beta diversity both groups was divergent from control group. genera Alloprevotella, Anaeroglobus, Acinetobacter, unclassified Bacteroidales, Cyanobacteriales significantly enriched group In contrast, microbiome mainly composed Haemophilus, Lautropia, Allorhizobium Neorhizobium Pararhizobium Rhizobium, Escherichia Shigella, Rhodobacteraceae. dominated by genre uncultured Candidatus Saccharibacteria bacterium, Clostridiales bacterium feline taxon 148, Treponema, Prevotellaceae, Mobiluncus, Acholeplasma. Rhodobacteraceae Aggregatibacter also that clinical indicators correlated saliva microbiome. Conclusion may connected