Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome

• DOI: 10.3389/fcimb.2023.1127369
• Publication Date: 2023-03-06T05:34:52Z
• Authors: Xiaomin Hu; Ziying Han; Ruilin Zhou; Wan Su; Liang Gong; Zihan Yang; Xiao Song; Shuyang Zhang; Huijun Shu; Dong Wu
• Keywords: Respiratory Distress Syndrome; acute pancreatitis; gut microbiota; acute respiratory distress syndrome; Microbiology; QR1-502; 3. Good health; Gastrointestinal Microbiome; Cellular and Infection Microbiology; Pancreatitis; RNA, Ribosomal, 16S; Acute Disease; biomarker; Humans; disease prediction

Acute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes gut microbiota have been shown to influence progression pancreatitis. We aimed determine whether early alterations related and could predict ARDS occurrence AP patients.In this study, we performed 16S rRNA sequencing analysis 65 patients 20 healthy volunteers. The were further divided into two groups: 26 AP-ARDS 39 AP-nonARDS based on during hospitalization.Our results showed that exhibited specific composition function as compared subjects group. Higher abundances Proteobacteria phylum, Enterobacteriaceae family, Escherichia-Shigella genus, Klebsiella pneumoniae, but lower Bifidobacterium genus found group groups. Random forest modelling revealed Escherichia-shigella was effective distinguish from AP-nonARDS, patients.Our study admission after hospitalization, indicating a potential predictive pathogenic role development patients.