Epidemiological characteristics of respiratory viruses in hospitalized children during the COVID-19 pandemic in southwestern China

• DOI: 10.3389/fcimb.2023.1142199
• Publication Date: 2023-04-04T13:29:08Z
• Authors: Lin Zhu; Tingting Luo; Yining Yuan; Shu Yang; Chao Niu; Ting Gong; Xueer Wang; Xiaohong Xie; Jian Luo; Enmei Liu; Zhou Fu; Daiyin Tian
• Keywords: Pandemic

Multinational studies have reported that the implementation of nonpharmaceutical interventions (NPIs) to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission coincided with decline other viruses, such as influenza viruses and syncytial virus.To investigate prevalence common during disease 2019 (COVID-19) pandemic.Respiratory specimens children lower tract infections (LRTIs) hospitalized at Children's Hospital Chongqing Medical University from January 1, 2018 December 31, 2021 were collected. Seven pathogens, including virus (RSV), adenovirus (ADV), A B (Flu A, Flu B), parainfluenza types 1-3 (PIV1-3), detected by a multiplex direct immunofluorescence assay (DFA). Demographic data laboratory test results analyzed.1) total 31,113 LRTIs enrolled, 8141 in 2018, 8681 2019, 6252 2020, 8059 2021.The overall detection rates decreased 2020 (P < 0.001). The RSV, ADV, PIV-1, PIV-3 when NPIs active February August decreasing most predominantly, 2.7% 0.3% 0.05). RSV PIV-1 resurged even surpassed historical level 2018-2019, while continued lifted 2) Seasonal patterns completely disappeared 2021. epidemic was observed until October after long period low 2020. sharply stayed nearly dormant state next seven months. Nevertheless, abnormally higher than 10% summer significantly COVID-19 pandemic; however, it atypically surged November 2020.The implemented pandemic affected seasonal certain PIV-3, viruses. We recommend continuous surveillance epidemiological evolutionary dynamics multiple especially are no longer necessary.