The preliminary evidence on the association of the gut microbiota with stroke risk stratification in South Chinese population

• DOI: 10.3389/fcimb.2023.1227450
• Publication Date: 2023-12-21T04:49:46Z
• Authors: Haiyan Huang; Zhuoran Kuang; Ruibi Mo; Miaomiao Meng; Yefeng Cai; Xiaojia Ni
• Keywords: Stroke

Aims This study aimed to investigate the association between gut microbiota and risk of stroke. Methods Faecal samples from 60 participants in South China, including 45 individuals with factors for stroke 15 healthy controls, were collected subjected 16S rRNA sequencing. A bioinformatics analysis was performed characterise microbial diversity taxonomic compositions at different levels (low, moderate, high) Functional prediction correlation analyses laboratory markers explore potential mechanisms. Results significant difference beta observed control groups. Linear discriminant effect size revealed a large number vascular beneficial bacteria enriched low-risk groups, but few harmful more abundant high-risk group than those other In addition, Anaerostipes , Clostridium_XlVb Flavonifractor all which belonged Firmicutes phylum, group, their relative abundances gradually decreased as increased. Spearman’s that these outstanding correlated triglycerides, high-density lipoprotein cholesterol, low-density white blood cells, neutrophils, carotid intima-media thickness. Conclusion The preliminary evidence suggests is associated risk. It potentially ameliorates atherosclerosis by targeting lipid metabolism inflammation. provides novel insights into early screening primary prevention.