Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy

• DOI: 10.3389/fcimb.2024.1354681
• Publication Date: 2024-09-18T13:11:05Z
• Authors: Brieuc Van Nieuwe...; Mathilde Balcaen; Olga Chatzis; Astrid Haenecour; Emilien Derycke; Thierry Detaille; Stéphan Clément d...; Cécile Boulanger; Leïla Belkhir; Jean-Cyr Yombi; Julien De Greef; Olivier Cornu; Pierre-Louis Docq...; Audrey Lentini; Renaud Menten; Hector Rodriguez-...; Alexia Verroken; Sarah Djebara; Maya Merabishvili; Johann Griselain; Jean-Paul Pirnay; Laurent Houtekie; Dimitri Van der L...
• Keywords: Male; Methicillin-Resistant Staphylococcus aureus; phage therapy; necrotizing fasciitis; Stenotrophomonas maltophilia; Bacterial Toxins; Panton and Valentine leukocidin (PVL); Exotoxins; MRSA; Staphylococcal Infections; Microbiology; QR1-502; Anti-Bacterial Agents; Cellular and Infection Microbiology; Treatment Outcome; bacteriophage; Leukocidins; Pseudomonas aeruginosa; Humans; Fasciitis, Necrotizing; Phage Therapy; Child; pediatric intensive care unit

Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.