Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain

• DOI: 10.3389/fcvm.2020.615507
• Publication Date: 2021-01-27T06:33:36Z
• Authors: Hélène David; Aurore Ughetto; Philippe Gaudard; Maëlle Plawecki; Nitchawat Paiyabh...; Emma Zub; Pascal Colson; Sylvain Richard; Nicola Marchi; Pierre Sicard
• Keywords: Hypoxia

Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes vascular oxygen saturation (sO 2 ) over time experimental MI multiple peripheral organs brain. Methods Results: Experimental was obtained BALB/c mice by permanent ligation of left anterior descending artery. PA (Vevo LAZR-X) allowed tracking mouse-specific sO kinetics cardiac ventricular (LV) wall, brain, kidney, liver at 4 h, 1 day, 7 days post-MI. reported correlation between LV longitudinal strain ( r = −0.44, p < 0.0001, n 96). Acute dysfunction associated with global hypoxia, specifically decrease level brain (−5.9%), kidney (−6.4%), (−7.3%) 24 h Concomitantly, preliminary examination capillary NG2DsRed pericytes indicated cell rarefication heart kidney. While tissue persistently impacted, levels returned pre-MI MI. Conclusions: Collectively, our data indicate that elicits precise trajectories hypoxia enabled synchronous oxygenation post-MI, potentially enabling translational diagnostic modality identification modifications this disease setting.