A Novel Risk Scoring Tool to Predict Saphenous Vein Graft Occlusion After Cardiac Artery Bypass Graft Surgery

• DOI: 10.3389/fcvm.2021.670045
• Publication Date: 2021-08-12T06:21:33Z
• Authors: Yujing Cheng; Xiaoteng Ma; Xiaoli Liu; Yingxin Zhao; Yan Sun; Dai Zhang; Qi Zhao; Yingkai Xu; Yujie Zhou
• Keywords: saphenous vein; 03 medical and health sciences; 0302 clinical medicine; risk factor; RC666-701; coronary artery bypass grafting; Diseases of the circulatory (Cardiovascular) system; graft occlusion; Cardiovascular Medicine; coronary artery disease; 3. Good health

Objectives: Coronary artery bypass grafting (CABG) success is reduced by graft occlusion. Understanding factors associated with occlusion may improve patient outcomes. The aim of this study was to develop a predictive risk score for saphenous vein (SVG) after CABG. Methods: This retrospective cohort enrolled 3,716 CABG patients from January 2012 March 2013. development included 2,477 and the validation 1,239 patients. baseline clinical data at index analyzed their independent impact on in our using Cox proportional hazards regression. scoring tool weighted beta coefficients final model. Concordance (c)-statistics comparison predicted observed probabilities were used discrimination calibration. Results: A total 959 (25.8%) out developed least one late SVG Significant female sex [beta (β) = 0.52], diabetes (β 0.21), smoking (currently) 0.32), hyperuricemia 0.22), dyslipidemia 0.52), prior percutaneous coronary intervention (PCI) rising number 0.12) lesion vessels 0.45). On-pump surgery −0.46) use angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) −0.59) calcium channel (CCB) −0.23) protective factors. 11 variables derivation cohort, which delineated each into quartiles. c-statistic model 0.71 cohort. Conclusions: An easy-to-use sex, diabetes, smoking, hyperuricemia, dyslipidemia, PCI, vessels, on-pump surgery, ACEI/ ARB CCB validated. accurately estimated (c-statistic 0.71).