Impact of Chronobiological Variation in Takotsubo Syndrome: Prognosis and Outcome

• DOI: 10.3389/fcvm.2021.676950
• Publication Date: 2021-08-27T21:55:36Z
• Authors: Ibrahim El-Battrawy; Assem Aweimer; Siegfried Lang; Uzair Ansari; Thorsten Gietzen; Niklas Ullrich; Andreas Mügge; Xiaobo Zhou; Martin Borggrefe; Ibrahim Akin
• Keywords: 03 medical and health sciences; 0302 clinical medicine; RC666-701; outcome; heart failure; Diseases of the circulatory (Cardiovascular) system; complication; Cardiovascular Medicine; takotsubo; chronobiology; 3. Good health

Background: A considerable amount of evidence has shown that acute cardiovascular diseases exhibit specific temporal patterns in their onset. Aim: This study was performed to determine if takotsubo syndrome (TTS) shows chronobiological variations with short and long-term impacts on adverse events. Design: Our institutional database constituted a collective 114 consecutive TTS patients between 2003 2015. Methods: Patients were divided into groups defined by the onset as per time day, day week, month quarter year. Results: events most common afternoon least night, indicating wave-like pattern ( p = 0.001) manifestation. The occurrence similar among days week weeks month. diagnosed November subsequently fourth showed significantly longer QTc interval. These also revealed lower event-free-survival over 1-year follow-up. In multivariate Cox regression analysis, occurring year (HR 6.8, 95%CI: 1.3–35.9; 0.02) proved be an independent predictor event-free-survival. Conclusions: seems preference its onset, but nevertheless this possibly coincidental result needs analyzed large multicenter registry.