Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary Bypass

• DOI: 10.3389/fcvm.2021.756269
• Publication Date: 2021-10-13T17:33:34Z
• Authors: Maxime Nguyen; Thomas Gautier; Guillaume Reocreux; Gaëtan Pallot; Guillaume Maquart; Pierre-Alain Bahr; Annabelle Tavernier; Jacques Grober; David Masson; Belaid Bouhemad; Pierre-Grégoire G...
• Keywords: Phospholipid transfer protein; High-density lipoprotein; Reverse cholesterol transport

Introduction: Lipopolysaccharide (LPS) is a component of gram-negative bacteria, known for its ability to trigger inflammation. The main pathway LPS clearance the reverse lipopolysaccharide transport (RLT), with phospholipid transfer protein (PLTP) and lipoproteins playing central roles in this process experimental animal models. To date, relevance has never been studied humans. Cardiac surgery cardiopulmonary bypass favor digestive translocation. Our objective was determine whether pre-operative PLTP activity triglyceride or cholesterol-rich lipoprotein concentrations were associated patients undergoing cardiac bypass. Methods: A post-hoc analysis conducted on plasma samples obtained from recruited randomized controlled trial.Total cholesterol, high density cholesterol (HDLc), low (LDLc), measured before surgery. concentration by mass spectrometry surgery, at end 24 h after admission intensive care unit. Results: High lower but not inflammation nor post-operative complications. HDLc, LDLc total developing adverse events. HDLc negatively biomarkers (CRP, PCT). Triglyceride positively correlated concentration, PCT higher Conclusion: study supports role elimination RLT human. activity, rich pool size seemed be limiting factor RLT. directly related events, suggesting that driver our patients. However, favorable outcomes, HDL beneficial anti-inflammatory effects could be, least part independent clearance.