Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study

• DOI: 10.3389/fcvm.2021.811670
• Publication Date: 2022-02-10T09:53:32Z
• Authors: Chang Liu; Liping Liu; Yinglu Wang; Xiaoli Chen; Jie Liu; Sheng Peng; Jingjiang Pi; Qi Zhang; Brain Tomlinson; Paul Chan; Lin Zhang; Huimin Fan; Liang Zheng; Zhongmin Liu; Yuzhen Zhang
• Keywords: Abdominal obesity; Hyperhomocysteinemia

Hyperhomocysteinemia (HHcy) and abdominal obesity are risk factors for metabolic syndrome (MetS) death from cardiovascular disease (CVD). Recent studies have shown a correlation between HHcy obesity, suggesting that they may combined effect on the of MetS CVD mortality. However, this suspicion remains to be confirmed, particularly in elderly population. We explored their effects mortality among community population aged 65 above China.This prospective study enrolled 3,675 Chinese residents May 2013 with 7-year follow-up all-cause was defined as blood homocysteine (Hcy) level >15 μmol/L waist circumference (WC) ≥90 cm men ≥80 women (HWC). All participants were grouped into four categories by WC Hcy: NWC (normal WC) /HHcy(-), NWC/HHcy(+), HWC/HHcy(-), HWC/HHcy(+). The relationship profile evaluated logistic regression analysis association Cox analysis. prevalence HHcy, 40.1, 59.3, 41.4%, respectively. Using group without [NWC/HHcy(-)] reference, other three groups had significantly higher its component abnormalities, HWC/HHcy(+) having highest (OR = 13.52; 95% CI 8.61-14.55). After median 6.94 (±1.48) years follow-up, 454 deaths occurred 135 deaths. Compared NWC/HHcy(-) group, (HR 1.75; 1.02-3.03) 1.23; 1.04-2.18) increased considerably after adjustment major factors.There is high increases MetS, CVD, mortality, especially populations obesity.