Intra-individual comparison of coronary calcium scoring between photon counting detector- and energy integrating detector-CT: Effects on risk reclassification

• DOI: 10.3389/fcvm.2022.1053398
• Publication Date: 2023-01-19T06:10:03Z
• Authors: Elias V. Wolf; Moritz C. Halfmann; U. Joseph Schoepf; Emese Zsarnoczay; Nicola Fink; Joseph P. Griffith; Gilberto J. Aquino; Martin J. Willemink; Jim O’Doherty; Michaela M. Hell; Pal Suranyi; Ismael M. Kabakus; Dhiraj Baruah; Akos Varga-Szemes; Tilman Emrich
• Keywords: Photon Counting

To compare coronary artery calcium volume and score (CACS) between photon-counting detector (PCD) conventional energy integrating (EID) computed tomography (CT) in a phantom prospective patient study. A commercially available CACS was scanned with standard protocol (120 kVp, slice thickness/increment 3/1.5 mm, quantitative Qr36 kernel), filtered back projection on the EID-CT, monoenergetic reconstruction at 70 keV quantum iterative off PCD-CT. The same settings were used to prospectively acquire data patients (n = 23, 65 ± 12.1 years), who underwent PCD- EID-CT scans median of 5.5 (3.0-12.5) days two period from August 2021 March 2022. quantified using software solution. regression formula obtained aforementioned comparison applied simulate risk reclassification pre-existing cohort 514 cardiac January December 2021. Based experiment, PCD-CT showed more accurate measurement reference CAC volumes (overestimation physical volumes: 66.1 1.6% vs. EID-CT: 77.2 0.5%). strongly correlated, however, latter measured significantly lower values (CACS : 60.5 (30.2-170.3) vs 74.7 (34.6-180.8), p 0.0015, r 0.99, mean bias -9.7, Limits Agreement (LoA) -36.6/17.3) (non-significant) 174.3 (11.1-872.7) 218.2 (18.5-876.4), 0.10, 0.94, -41.1, LoA -315.3/232.5). systematic measurements Agatston system led 5.25% our simulated classification class. is feasible correlates , leads values. may provide results that are for than EID-CT.