Right Atrial Fluorodeoxyglucose Uptake Is a Risk Factor for Stroke and Improves Prediction of Stroke Above the CHA2DS2-VASc Score in Patients With Atrial Fibrillation

• DOI: 10.3389/fcvm.2022.862000
• Publication Date: 2022-07-08T04:31:27Z
• Authors: Bing Wang; Yiduo Xu; Peng Wan; Shan Shao; Feifei Zhang; Xiaoliang Shao; Jianfeng Wang; Yuetao Wang
• Keywords: Stroke

Atrial fibrillation (AF) is a common arrhythmia, and its most severe dreaded complication stroke. The CHA2DS2-VASc score currently recommended for stroke risk assessment in AF. We aimed to explore the relationship between atrial FDG uptake whether could provide incremental value above CHA2DS2-VAS predict AF by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT).From September 2017 December 2020, we retrospectively enrolled 230 patients (115 with 115 without as non-AF group, matched date of PET/CT examination basic characteristics patient) who underwent 18F-FDG due tumor screening or preoperative staging after prolonged fasting followed up at least 12 months from examination; endpoint event occurrence visually quantitatively analyzed right left atria (RA/LA), appendage (RAA/LAA), ventricle (RV/LV), collected clinical features. In addition, according (stroke), population was divided into group non-stroke relevant features indicators two groups were analyzed. Univariate multivariate Cox regression analyzes used analyze factors events. Kaplan-Meier survival curve drawn, log-rank method compare differences curves groups. Receiver operating characteristic (ROC) examine discriminatory power predicting determine addition improves predictive beyond stroke.In more than half had RA one-fifth LA uptake, while one patient group. quantitative analysis, maximum standardized (SUV max ) significantly higher that (all P < 0.001). 28 ± 10 months, finally, 31 fibrillation, SUV , RAA LAA age ≥ 75 years, dilation those 0.05). Multivariate analysis showed high (RA 2.62) an independent factor (HR = 4.264, 95% CI 1.368-13.293, 0.012). By using test, incidence compared low (P Addition effectively, larger AUC 0.790 0.001).This study found significant correlation AF, especially RA. Meanwhile, stroke, have Moreover, prediction