Clinical and Cardiovascular Magnetic Resonance Predictors of Early and Long-Term Clinical Outcome in Acute Myocarditis

• DOI: 10.3389/fcvm.2022.886607
• Publication Date: 2022-04-29T04:58:48Z
• Authors: Yohann Bohbot; Jérôme Garot; Thomas Hovasse; Thierry Unterseeh; Chloé Di Lena; Wahiba Boukefoussa; Chloé Tawa; Cédric Renard; Isabelle Limouzineau; Suzanne Duhamel; Philippe Garot; Christophe Tribou...; Francesca Sanguineti
• Keywords: Mace; Clinical endpoint; Acute myocarditis

The natural history of acute myocarditis (AM) remains partially unknown and predictors outcome are debated. We sought to assess the impact various cardiac magnetic resonance (CMR) parameters on early long-term prognosis in a population patients with AM.In two-center longitudinal study, we included consecutive diagnosis AM based CMR without hemodynamic compromise. primary endpoint was occurrence an event phase (≤15 days). Secondary endpoints were major adverse events (MACE) recurrence during follow-up.Three hundred eighty-eight [mean age 38.5 years, 77.3% male, mean ejection fraction (EF):56%] which 82% (317) presented chest pain. performed 4 ± 2 days after index presentation. Overall, 38 (9.8%) had at phase, 41 (10.6%) least one MACE follow-up (median 7.5 6.6-8.9) 30 (7.7%) experienced AM. By multivariate analysis, independent initial complications absence pain (OR [95%CI] = 0.35 [0.15-0.82]), presence syncope/pre-syncope 3.56 [1.26-10.02]), lower EF 0.94 [0.91-0.98] per%), myocardial extent late gadolinium enhancement (LGE) 1.05 [1.002-1.100] per%) edema 0.44 [0.19-0.97]). Only (HR 1.021 [1.001-1.041] per year) alteration [0.91-0.97] associated follow-up. Factors independently prior episodes 5.74 [1.72-19.22]) viral syndrome episode 4.21 [1.91-9.28]).In routine hemodynamically stable CMR, edema, reduced EF, LGE outcome. events.