Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals

• DOI: 10.3389/fcvm.2022.889985
• Publication Date: 2022-06-06T06:08:40Z
• Authors: Ana Cristina Leandro; Laura F. Michael; Marcio Almeida; Mikko Kuokkanen; Kevin Huynh; Corey Giles; Thy Duong; Vincent P. Diego; Ravindranath Dugg...; Geoffrey D. Clarke; John Blangero; Peter J. Meikle; Joanne E. Curran
• Keywords: Lipidome; Epicardial Fat

Introduction Cardiovascular disease (CVD) is the leading cause of mortality worldwide and death in US. Lipid dysregulation a well-known precursor to metabolic diseases, including CVD. There growing body literature that suggests MRI-derived epicardial fat volume, or adipose tissue (EAT) linked development coronary artery disease. Interestingly, also actively involved lipid energy homeostasis, with having greater capacity for release uptake free fatty acids. However, there scarcity knowledge on influence plasma lipids EAT volume. Aim The focus this study identification novel lipidomic species associated CMRI-derived measures Mexican American individuals. Methods We performed profiling 200 High-throughput mass spectrometry enabled rapid capture precise profiles, providing 799 unique from circulating samples. Because our extended pedigree design, we utilized standard quantitative genetic linear mixed model analysis determine whether were correlated by formally testing association between each CMRI phenotype. Results After correction multiple using FDR approach, identified 135 showing significant fat. Of those, 131 positively EAT, where increased levels top 10 an volume deoxyceramide (Cer(m)) triacylglycerol (TG) families. Deoxyceramides are atypical neurotoxic sphingolipids. Triacylglycerols abundant class comprise bulk storage tissues. Pathologically elevated TG Cer(m) related CVD risk and, study, Conclusion Our results indicate specific abnormalities such as enriched saturated triacylglycerols presence toxic ceramides individuals could precede