Association Between a Novel Metabolic Score for Insulin Resistance and Mortality in People With Diabetes

• DOI: 10.3389/fcvm.2022.895609
• Publication Date: 2022-05-12T06:04:17Z
• Authors: Zhenwei Wang; Jing Xie; Junjie Wang; Wei Feng; Naifeng Liu; Yun Liu
• Keywords: Association (psychology)

Background Growing studies have shown that insulin resistance (IR) is associated with poor prognoses among patients diabetes, whereas the association between IR and mortality has not been determined. Hence we aimed to evaluate associations all-cause, cardiovascular diseases (CVDs) cancer-related in diabetes. Methods We enrolled 2,542 participants diabetes an average age of 57.12 ± 0.39 years 52.8% men from 1999–2014 National Health Nutrition Examination Survey (NHANES 1999–2014). A novel metabolic score for (METS-IR) was considered as alternative marker IR. Mortality data were obtained Death Index records all followed up until December 31, 2015. Cox proportional hazards regression, restricted cubic spline Kaplan-Meier survival curves performed METS-IR all-cause cause-specific Results During 17,750 person-years follow-up [median (months), 95% CI: 90, 87–93], 562 deaths documented, including 133 CVDs-related 90 deaths. Multivariate regression showed compared Quintile 1 (METS-IR ≤ 41), 2, 3, 4 (Q2 vs. Q1: HR 0.65, CI 0.49–0.87, P = 0.004; Q3 0.69, 0.50–0.96, 0.029; Q4 0.57, 0.36–0.91, 0.019; respectively). Restricted indicated non-linearly mortality. Threshold effect analyses determined threshold values both 33.33. Only below negatively (HR 0.785, 0.724–0.850, < 0.001; 0.722, 0.654–0.797, Sensitivity when excluding who died within follow-up, results remained consistent, CVDs, only correlated Subgroup mortality, still stable subgroups except newly diagnosed but persisted 65 years, male, White, non-White, already or uesd oral drugs, insulin, sensitizing drugs. Conclusion