Serum Cytokines Predict the Severity of Coronary Artery Disease Without Acute Myocardial Infarction

• DOI: 10.3389/fcvm.2022.896810
• Publication Date: 2022-05-16T06:13:52Z
• Authors: Sheng Liu; Chenyang Wang; Jinzhu Guo; Yunxiao Yang; Mengling Huang; Li Li; Yu Wang; Yanwen Qin; Ming Zhang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; RC666-701; interleukin-17 (IL-17); high-density lipoprotein cholesterol (HDL-C); interleukin-12 (IL-12); Diseases of the circulatory (Cardiovascular) system; Cardiovascular Medicine; cytokines; coronary artery disease; 3. Good health

Various cytokines were involved in the process of atherosclerosis, and their serum levels correlated with coronary artery disease (CAD) to varying degrees. However, there limited reports about correlation between severity atherosclerotic lesion patients non-acute myocardial infarction (AMI). The purpose this study was investigate relationship CAD, identify predictors severe CAD suspected have but AMI had been ruled out.A total 502 who underwent angiography enrolled. IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, TNF-α, IFN-α,and IFN-γ determined by multiplexed particle-based flow cytometric assays technology. And evaluated Gensini score (GS).The IFN-α significantly lower group (GS≥30) than those non-severe (GS < 30). IL-12p70 IL-17 negatively CAD. Multivariate logistic regression analyses demonstrated that two (IL-12p70 IL-17), one clinical protective factor (HDL-C), risk factors (gender diabetes) independent ROC curve analysis showed multivariate mode combined these a good performance predicting CAD.The combination IL-17) (HDL-C, gender, may help more lesions from not AMI, contribute guiding stratification for chest discomfort health care facilities without sufficient medical resources (especially cardiac catheterization resources).