Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

• DOI: 10.3389/fcvm.2022.944506
• Publication Date: 2022-09-08T08:01:16Z
• Authors: Xiaojie Liu; Tiajun Li; Hui Xu; Chunhua Wang; Xiaojun Ma; Hui Huang; Yanling Hu; Haichen Chu
• Keywords: 03 medical and health sciences; trauma; 0302 clinical medicine; RC666-701; immobilization; Diseases of the circulatory (Cardiovascular) system; hyperglycemia; glucose; Cardiovascular Medicine; deep vein thrombosis; 3. Good health

Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 who underwent fracture January 2017 March 2022 at Affiliated Hospital of Qingdao University were queried institutional electronic medical records. A total population 1,086 was identified, comprising 138 experienced DVT 948 controls. The primary outcome DVT. Multiple logistic regression analyses performed a receiver operating characteristic (ROC) curve generated. Age, D-dimer level, RBC count, level independent predictors two highest categories (≥ 960, < 2,102; ≥ 2,102 ng/ml) increased odds ratio by 4.215 times [95% confidence interval (CI) 1.820-9.761] 7.896 (95% CI 3.449-18.074), respectively, compared lowest reference category (< 490 ng/ml). area under (AUC) 0.605. Hyperglycemia (glucose 6.1, 7.0 mmol/l) 1.889-fold (1.085-3.291); p 0.0001] euglycemia 6.1 mmol/l). We therefore observed an hyperglycemia fractures. There are several modalities controlling hyperglycemia, offering potential targets future improvement.