Recurrent acute myocarditis: An under-recognized clinical entity associated with the later diagnosis of a genetic arrhythmogenic cardiomyopathy

• DOI: 10.3389/fcvm.2022.998883
• Publication Date: 2022-10-28T05:25:56Z
• Authors: Pierre Ollitrault; Mayane Al Khoury; Yann Troadec; Yoann Calcagno; Laure Champ-Rigot; Virginie Ferchaud; Arnaud Pellissier; Damien Legallois; Paul Milliez; Fabien Labombarda
• Keywords: Acute myocarditis

Myocardial inflammation has been consistently associated with genetic arrhythmogenic cardiomyopathy (ACM) and it hypothesized that episodes mimicking acute myocarditis (AM) could represent early inflammatory phases of the disease.We evaluated temporal association between recurrent (RAM) later diagnosis a ACM.Between January 2012 December 2021, patients RAM no previous were included (Recurrent Acute Myocarditis Registry, NCT04589156). A follow-up visit including clinical evaluation, resting stress electrocardiogram, cardiac magnetic resonance imaging, testing was carried out. Endpoints study incidence both ACM criteria mutation at end follow-up.Twenty-one completed in 19/21 (90%). At follow-up, 3.3 ± 2.9 years after last AM episode, 14/21 (67%) an phenotype (biventricular: 10/14, 71%; left ventricular: 4/14, 29%) underwent testing. pathogenic or likely found 8/14 (57%), 5/8 Desmoplakin gene, 2/8 Plakophillin-2 1/8 Titin gene. Family history sudden death had positive predictive value 88% for presence underlying RAM.RAM is rare entity latter more than third cases. In those patients, disease. Including might allow potential therapeutic interventions.