Higher risk of cardiovascular mortality than cancer mortality among long-term cancer survivors

• DOI: 10.3389/fcvm.2023.1014400
• Publication Date: 2023-01-25T09:03:19Z
• Authors: Zhipeng Wang; Zeyu Fan; Lei Yang; Lifang Liu; Chao Sheng; Fengju Song; Yubei Huang; Kexin Chen
• Keywords: Cardiotoxicity

Previous studies focused more on the short-term risk of cardiovascular (CV) death due to traumatic psychological stress after a cancer diagnosis and acute cardiotoxicity anticancer treatments than long-term CV death.Time trends in proportions (PCV), (PCA), other causes deaths from all were used show preliminary relationships among three 4,806,064 patients with Surveillance, Epidemiology, End Results (SEER) program. Competing mortality curves investigate when cumulative rate (CMRCV) began outweigh (CMRCA) for who survived 10 years. Multivariable competing models further potential factors associated death.For at sites, PCV increased 22.8% 5th year 31.0% 10th 35.7% 20th year, while PCA decreased 57.7% 41.2 29.9% respectively. The outweighed (34.6% vs. 34.1%) since 15th as early 9th colorectal (37.5% 33.2%) late 22nd breast (33.5% 30.6%). CMRCV CMRCA 25th diagnosis. Multivariate showed that an was independently older age [hazard ratio 95% confidence intervals [HR (95%CI)] 43.39 (21.33, 88.28) ≥ 80 ≤ 30 years] local metastasis [1.07 (1.04, 1.10)] women [0.82 (0.76, 0.88)], surgery [0.90 (0.87, 0.94)], chemotherapy [0.85 (0.81, 0.90)] Further analyses 20 years sensitivity by sites similar results.CV gradually outweighs survival time increases most cancer. Both cardio-oncologist cardio-oncology care should be involved reduce survivors.