A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease

• DOI: 10.3389/fcvm.2023.1153625
• Publication Date: 2023-05-17T05:26:16Z
• Authors: Yan Liu; Da Huang; Zhile Li; LiuFang Zhou; Tuan Cen; Baomin Wei; Liuqing Wei; Hongying Wu; Liye Su; Suren R. Sooranna; Xinshou Pan; ZhaoHe Huang
• Keywords: Pathogenesis; Proteome; Pathophysiology

Aims The pathogenesis of disease progression targets for patients with heart failure after acute myocardial infarction was investigated by using plasma proteomics. Methods proteomes (MI-HF) and without (MI-WHF) were compared. Each group consisted 10 who matched age sex. peptides analyzed 2-dimensional liquid chromatography coupled to tandem mass spectrometry in a high definition mode. Parallel reaction monitoring (PRM) verified the selected target proteins. Results We identified quantified 2,589 2,222 proteins, respectively, found 117 differentially expressed proteins (DEPs) (≥1.5-fold), when MI-HF MI-WHF groups Of these 51 66 significantly up-regulated down-regulated, respectively. significant DEPs subjected protein–protein interaction network analysis which revealed central role NF-κB signaling pathway patients. PRM that MB, DIAPH1, VNN1, GOT2, SLC4A1, CRP, CKM, SOD3, F7, DLD, PGAM2, GOT1, UBA7 HYOU1 14 highly Conclusions These findings showed related poor outcomes experiencing MI-HF. may be useful candidate markers diagnosis as well help elucidate pathophysiology this major cause mortality older