Visualization of electrographic flow fields of increasing complexity and detection of simulated sources during spontaneously persistent AF in an animal model

• DOI: 10.3389/fcvm.2023.1223481
• Publication Date: 2023-09-01T07:37:50Z
• Authors: Melissa H. Kong; Steven Castellano; Peter Ruppersberg; Ken S. Lizama; Boaz Avitall
• Keywords: RC666-701; electrographic flow; Diseases of the circulatory (Cardiovascular) system; atrial fibrillation; mapping; arrythmia; Cardiovascular Medicine; focal activation; 3D

Mapping algorithms have thus far been unable to localize triggers that serve as drivers of AF, but electrographic flow (EGF) mapping provides an innovative method estimating and visualizing in vivo, near real-time cardiac wavefront propagation.One-minute unipolar EGMs were recorded the right atrium (RA) from a 64-electrode basket catheter generate EGF maps during atrial rhythms increasing complexity. They obtained 3 normal, animals sinus rhythm (SR) 6 which persistent AF was induced by rapid pacing. Concurrent high-resolution bipolar at location all EGF-identified sources acquired. Pacing subsequently conducted create focal accuracy source detection pacing site assessed subthreshold, threshold high-output ipsilateral or contralateral atria (n = 78).EGF recordings showed strong coherent emanating node SR changed direction blocked ablation lesions. Additional passive rotational phenomena lower activity visualized flutter (AFL) AF. During recordings, not found be correlated dominant frequency f wave amplitude observed concurrently EGMs. While subthreshold did affect map properties above created active could accurately localized without any spurious 95% cases when covered source.EGF can used visualize patterns identify animal model. Source spectral f-waves The locations pinpointed with high precision, suggesting they may prime targets for ablations.