A pilot clinical assessment of biphasic asymmetric pulsed field ablation catheter for pulmonary vein isolation

• DOI: 10.3389/fcvm.2024.1266195
• Publication Date: 2024-02-07T04:41:31Z
• Authors: Bingwei Chen; Chang Lv; Yingjian Cui; Chengzhi Lu; Heng Cai; Zhixiao Xue; Xinyu Xu; Siying Su
• Keywords: 0301 basic medicine; 03 medical and health sciences; RC666-701; biphasic asymmetric pulse; pilot clinical assessment; Diseases of the circulatory (Cardiovascular) system; atrial fibrillation; pulsed field ablation; Cardiovascular Medicine; pulmonary vein isolation

Pulsed field ablation (PFA) is a new treatment for atrial fibrillation (AF), and its selective characteristics give it significant advantage in treatment. In previous cellular animal experiments, we have demonstrated that biphasic asymmetric pulses can be used to ablate myocardial tissue. However, small-scale clinical trials are needed test whether this approach safe feasible before extensive performed. Therefore, the purpose of experiment determine safety feasibility patients with AF lay foundation larger trial. Ablation was performed 10 using pulses. Voltage mapping after PFA operation help us detect change electrical voltage pulmonary veins (PV). 3-Dimensional system showed continuous low potential site, vein isolation (PVI) achieved all four PV patients. There were no recurrences, stenosis, or other serious adverse events during 12 months follow-up. The results suggest waveforms safe, durable, effective trial could begin. Clinical Trial Registration https://www.chictr.org.cn/ , identifier, ChiCTR2100051894.