Causal role of immune cells in hypertension: a bidirectional Mendelian randomization study

• DOI: 10.3389/fcvm.2024.1375704
• Publication Date: 2024-05-27T04:26:35Z
• Authors: Xinhe Zhang; Guanying Li; Wei Wu; Bin Li
• Keywords: Mendelian Randomization; Pleiotropy

Background Although Hypertension (HTN) is considered to be a cardiovascular disease caused by multiple factors, the cause of it still unknown. In this study, we aim find out whether circulating immune cell characteristics have an impact on susceptibility HTN. Methods This study employed comprehensive two-sample Mendelian randomization (MR) analysis investigate causal association between and Utilizing publicly accessible genetic data, examined relationship HTN 731 signatures. To ensure reliability validity findings, sensitivity was conducted assess heterogeneity, confirm robustness results evaluate presence horizontal pleiotropy. Results After FDR correction, phenotype had effect our one immunophenotype identified as being positively associated with risk significance: HLA DR CD33- DR+. addition, 8 no statistically significant HTN, but worth mentioning that they unadjusted low P -value phenotype. Conclusions Our MR means demonstrated close cells, thus providing guidance for future clinical prediction subsequent treatment