Predictive value of combining urinary N-acetyl-β-D-glucosaminidase and serum homocysteine for contrast-induced nephropathy in patients after percutaneous coronary intervention

• DOI: 10.3389/fcvm.2024.1423836
• Publication Date: 2024-08-20T04:56:18Z
• Authors: Yiling Zhai; Changjun Luo; Nianying Qin; Hongying Cao; Chunyang Dong; Zhou Huang; Dongling Huang; Fan Wang; Wanxia Wei; Jincheng Li; Jie Yang; Xueling Lu; Zhengzhuang Huang; Wei Wang
• Keywords: Contrast-Induced Nephropathy

Background Contrast-induced nephropathy (CIN) can lead to serious complications following percutaneous coronary intervention (PCI). Urine N-Acetyl-β-D-glucosaminidase (uNAG) and serum homocysteine (sHCY) are both potential predictors for CIN detection, but their combination has not been explored. We aimed combine uNAG sHCY as the early detection of prognosis prediction in patients after PCI. Methods A total 232 consecutive who underwent PCI at a university hospital were recruited this study. According European Society Urology Reproduction (ESUR) criterion, is defined an elevation creatinine (sCr) by ≥25% or ≥0.5 mg/dl from baseline within 48 h. assessed use individual biomarkers (uNAG sHCY) measured around combinations prediction. Receiver operating characteristic curves (ROC) area under curve (AUC) used evaluate predictive efficiency predictors. Results In total, 54 (23.28%) developed CIN. Concentrations increased significantly subjects ( p < 0.05) than non-CIN. could be predicted stage. At pre-PCI, 0, 12, 24, h PCI, AUC-ROC value calculating was 0.594, 0.603, 0.685, 0.657, 0.648, respectively. The 0.726, 0.771, 0.755, 0.821, panel plus detected with higher accuracy either biomarker alone earlier sCr. For detecting CIN, yielded AUC-ROCs 0.693, 0.754, 0.826, 0.796, 0.844 respectively, which superior those biomarkers. predicting incidence major adverse cardiovascular events (MACE) 30 days 12 months, values before discharge 0.637 combined 0.832. did enhance capability MACE group non-CIN showed no significant difference Coronary Heart Disease Intensive Care Unit (CCU) stay time, demand renal replacement therapy, CCU mortality rate, in-hospital rate. Conclusions demonstrated better sensitivity specificity diagnosis these revealed discriminative performance compared using alone.