Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study

• DOI: 10.3389/fendo.2021.615913
• Publication Date: 2021-03-05T06:58:30Z
• Authors: Yu Jing; Jie Shi; Bin Lu; Weiwei Zhang; Yehong Yang; Jie Wen; Renming Hu; Zhen Yang; Xuanchun Wang
• Keywords: Cathepsin S; Univariate analysis

Background Cathepsin S, as an adipokine, was reported to play a critical role in various disease, including atherosclerosis and diabetes. The present study aims elucidate the relationship between circulating cathepsin S cardiovascular disease (CVD) patients with type 2 Methods A total of 339 diabetes individuals were enrolled this cross-sectional community-based study. Basic information, medical laboratory data collected. Serum levels assessed by ELISA. Results Compared CVD (−) group, serum significantly higher (+) median 23.68 ng/ml (18.54–28.02) 26.81 (21.19–37.69) respectively ( P < 0.001). Moreover, acute coronary syndrome (ACS) had substantially than those stable angina pectoris (SAP), 34.65 (24.33–42.83) 25.52 (20.53–31.47) 0.01). spearman correlation analysis showed that correlated several risk factors. univariate multivariate logistic regression revealed independent factor for (all 0.001) after adjustment potential confounders. Restricted cubic spline linearity association CVD. In addition, receiver operating characteristic (ROC) curve demonstrated area under (AUC) values 0.80 (95% CI: 0.75–0.84, 0.001), optimal cutoff value 26.28 ng/ml. Conclusion Circulating group one among increased associated risks CVD, even adjusting Thus, might be diagnostic biomarker