The Association Between Genetically Predicted Systemic Inflammatory Regulators and Polycystic Ovary Syndrome: A Mendelian Randomization Study

• DOI: 10.3389/fendo.2021.731569
• Publication Date: 2021-09-27T15:42:02Z
• Authors: Hanxiao Chen; Yaoyao Zhang; Shangwei Li; Yuanzhi Tao; Rui Gao; Wenming Xu; Yihong Yang; Kemin Cheng; Yan Wang; Lang Qin
• Keywords: Mendelian Randomization; Genome-wide Association Study; Pathogenesis; Genetic Association

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic diseases among women reproductive age. Inflammation may be involved in pathogenesis PCOS, but its exact relationship with PCOS remains unclear. Herein, we investigate causal association between systemic inflammatory regulators risk through a two-sample Mendelian randomization (MR) approach based on latest largest genome-wide study (GWAS) 41 8293 Finnish participants GWAS meta-analysis consisting 10,074 cases 103,164 controls European ancestry. Our results suggest that higher levels IL-17 SDF1a, as well lower SCGFb IL-4, are associated an increased (OR = 1.794, 95% CI 1.150 - 2.801, P 0.010; OR 1.563, 1.055 2.315, 0.026; 0.838, 0.712 0.986, 0.034; 0.637, 0.413 0.983, 0.042, respectively). In addition, genetically predicted related to IL-2 VEGF 1.257, 1.022 1.546, 0.030 1.112, 1.006 1.229, 0.038, indicate essential role cytokines PCOS. Further studies warranted assess possibility these biomarkers targets for prevention treatment.