The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

• DOI: 10.3389/fendo.2022.882241
• Publication Date: 2022-05-20T12:55:12Z
• Authors: Yuyan Shen; Xin Huang; Junyun Wu; Xiling Lin; Xiao Zhou; Zhiang Zhu; Xiaowen Pan; Jingya Xu; Jie Qiao; Tianyue Zhang; Linxia Ye; Hongwei Jiang; Yuezhong Ren; Peng-Fei Shan
• Keywords: China; disability-adjusted life years (DALYs); global burden; RC648-665; Global Health; osteoporosis; Diseases of the endocrine glands. Clinical endocrinology; Global Burden of Disease; 3. Good health; 03 medical and health sciences; Endocrinology; 0302 clinical medicine; fracture; death; low bone mineral density; Humans; Osteoporosis; Quality-Adjusted Life Years

Background Low bone mineral density (LBMD), including osteoporosis and low mass, has becoming a serious public health concern. We aimed to estimate the disease burden of LBMD its related fractures in 204 countries territories over past 30 years. Methods collected detailed information performed secondary analysis for from Global Burden Disease Study 2019. Numbers age-standardized rates disability-adjusted life-years (DALYs) deaths were compared by age, gender, socio-demographic index (SDI), location. Results DALYs number attributable increased 207 367 8 588 936 1990 437 884 16 647 466 2019, with raise 111.16% 93.82%, respectively. LBMD-related 121.07% 148.65% 4 436 789 121248 9 808 464 301 482 In five highest India (2 510 288), China (1 839 375), United States America (819 445), Japan (323 094), Germany (297 944), accounting 25.59%, 18.75%, 8.35%, 3.29%, 3.04%. There was quadratic correlation between (SDI) fractures: rate 179.985-420.435SDI+417.936SDI 2 (R = 0.188, p<0.001); Deaths 7.879-13.416SDI+8.839 SDI 0.101, p<0.001). Conclusions The global associated significantly since 1990. differences regions countries. These estimations could be useful priority setting, policy-making, resource allocation prevention treatment.