The Essential Role of Body Weight in Adjusting Gn Dosage to Prevent High Ovarian Response for Women With PCOS During IVF: A Retrospective Study

• DOI: 10.3389/fendo.2022.922044
• Publication Date: 2022-07-01T04:58:05Z
• Authors: Rujun Zeng; Hanxiao Chen; Xun Zeng; Lang Qin
• Keywords: Body Weight; Fertilization in Vitro; RC648-665; Diseases of the endocrine glands. Clinical endocrinology; 3. Good health; Gonadotropin-Releasing Hormone; body weight; Ovarian Hyperstimulation Syndrome; 03 medical and health sciences; Endocrinology; Hormone Antagonists; 0302 clinical medicine; Ovulation Induction; Humans; Female; gonadotropin; polycystic ovarian syndrome; in vitro fertilization; ovarian response; Gonadotropins; Polycystic Ovary Syndrome; Retrospective Studies

Polycystic ovarian syndrome (PCOS) is the major cause of anovulatory infertility. Since women with PCOS are often accompanied by increased body weight and hyper response to controlled stimulation, individualized gonadotropin (Gn) dose required achieve a therapeutic effect while minimizing risk hyperstimulation simultaneously. We aimed investigate essential role in optimizing initial Gn dosage for patients during vitro fertilization (IVF). retrospectively included 409 infertile who used gonadotropin-releasing hormone (GnRH)-antagonist fixed protocol underwent their first cycle IVF West China Second University Hospital from January 2019 June 2021. Baseline characteristics stimulation parameters, reproductive outcomes were compared between different weights responses. Multivariable linear regression analyses adopted relationship dosage. Receiver operating characteristic (ROC) curves drawn find optimal cut-off value predicting starting so as prevent high (HOR). found that luteinizing (LH) level Anti-Mullerian (AMH) lowest group over 70 kg was highest less than 50 kg. Increased significantly correlated rise (Beta = 0.399, t 8.921, p < 0.001). Normal (NOR) had fresh cancel rate (OHSS) which outweighed fewer embryos HOR patients. Using ROC curves, 53.25 (sensitivity, 84.2%; specificity, 53.8%) 70.5 58.8%; 93.0%) identified values predict no more 150 IU 225 IU, respectively. In conclusion, adjusting based on crucial preventing not influencing IVF.